Stockholm (AFP) – A trio of U.S. and German scientists won the Nobel Prize for Medicine on Monday for pioneering work on the body’s cell transport system, unlocking insights into diabetes, immune disorders and other diseases.
James Rothman and Randy Schekman of the United States and Thomas Suedhof of Germany shared the prize for discovering how molecules vital to cellular functioning are shunted around in an internal freight system, tucked inside sacs called vesicles.
They also helped resolve how the vesicles arrive on time and in the right place — a major riddle, given that this takes place in a microscopic environment humming with movement.
If the package fails to show up at the right time, or goes to the wrong location, this can cause cellular malfunction.
“Through their discoveries, Rothman, Schekman and Suedhof have revealed the exquisitely precise control system for the transport and delivery of cellular cargo,” the Nobel panel said.
“Without this wonderfully precise organisation, the cell would lapse into chaos.”
Rothman is a professor and chairman of the department of cell biology at Yale University; Schekman is a professor of molecular and cell biology at the University of California at Berkeley; and Suedhof is a professor of molecular and cellular physiology at Stanford University, also in California.
Schekman, 64, told AFP he was shocked to get the call from Stockholm: “My reaction when I heard about it was one of disbelief and joy.”
Rothman, 62, told Swedish Radio he was “profoundly honored.”
“I was completely shocked and surprised,” he said in separate comments posted on the Nobel website.
“Almost anyone who receives the Nobel prize has some indirect knowledge of one sort or another that they might be a candidate, so at some level it’s not a complete surprise. But that it actually happens is an out-of-body experience,” he said.
Three hours after the announcement, the Nobel Committee said it had still not managed to reach Suedhof, 58, to inform him of his prize, and Suedhof himself had yet to acknowledge it publicly.
The trio worked independently on various aspects of the vesicle system, in research spanning three-and-a-half decades.
Schekman began his investigations in the late 1970s, when he became interested in cellular genetics, using yeast as a model for study.